User:Tilman Schirmer/Sandbox 203

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C-di-GMP receptors with PilZ domain

PlzD


PlzD from Vibrio cholerae is composed of a YcgR-N* and a C-terminal PilZ domain (with very similar fold).

The c-di-GMP binding site is formed by arginine residues of the inter-domain linker and the PlzD domain surface (blow-up with labels).

PlzD in complex with c-di-GMP


Upon complex formation the relative domain arrangement is drastically changed (compare with 1yln above), see also blow-up.